Cyclin A2 Induces Cardiac Regeneration After Myocardial Infarction and Prevents Heart Failure
نویسندگان
چکیده
منابع مشابه
Cyclin A2 induces cardiac regeneration after myocardial infarction and prevents heart failure.
Mammalian myocardial infarction is typically followed by scar formation with eventual ventricular dilation and heart failure. Here we present a novel model system in which mice constitutively expressing cyclin A2 in the myocardium elicit a regenerative response after infarction and exhibit significantly limited ventricular dilation with sustained and remarkably enhanced cardiac function. New ca...
متن کاملCyclin A2 Induces Cardiac Regeneration After Myocardial Infarction and Prevents Heart
Mammalian myocardial infarction is typically followed by scar formation with eventual ventricular dilation and heart failure. Here we present a novel model system in which mice constitutively expressing cyclin A2 in the myocardium elicit a regenerative response after infarction and exhibit significantly limited ventricular dilation with sustained and remarkably enhanced cardiac function. New ca...
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BACKGROUND Heart failure is a global health concern. As a novel therapeutic strategy, the induction of endogenous myocardial regeneration was investigated by initiating cardiomyocyte mitosis by expressing the cell cycle regulator cyclin A2. METHODS AND RESULTS Lewis rats underwent left anterior descending coronary artery ligation followed by peri-infarct intramyocardial delivery of adenoviral...
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OBJECTIVES We assessed the effects of erythropoietin (EPO) treatment in a rat model of post-myocardial infarction (MI) heart failure. BACKGROUND Erythropoietin, traditionally known as a hematopoietic hormone, has been linked to neovascularization. Whereas administration of EPO acutely after MI reduces infarct size and improves cardiac function, its role in the failing heart is unknown. METH...
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Objectives: The primary purpose of this study was to determine the methods and means of prevention and treatment of coronary artery disease. In this study, we used a new regimen on heart rate and functional capacity of patients after myocardial infarction. This study also determines the effect of a new regimen on these factors. Methods: The cross sectional study was designed to assess the clin...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2007
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.107.153544